Christina Applegate’s Daughter Shares Insights on POTS Syndrome and Misophonia


In a heartfelt and enlightening podcast episode, Christina Applegate and her daughter, Sadie Grace LeNoble, discussed their personal experiences with chronic conditions. The episode, part of the podcast “MeSsy,” co-hosted by Applegate and Jamie-Lynn Sigler, offered listeners a glimpse into their lives, marked by both struggles and resilience.

Christina Applegate’s Multiple Sclerosis Diagnosis

In August 2021, Christina Applegate, the beloved actress known for her roles in “Dead to Me” and “Married with Children,” announced that she had been diagnosed with multiple sclerosis (MS). This chronic illness, which affects the central nervous system, brought significant changes to her life. Despite the challenges, Applegate has been remarkably candid about her journey, sharing her experiences openly with the public.

The Mother-Daughter Dynamic

The bond between Applegate and her daughter, Sadie, is a testament to the strength of their relationship. The duo has navigated the ups and downs of living with MS together, finding ways to support and learn from each other. Sadie’s presence has been a source of joy and motivation for Applegate, who often refers to her daughter as the reason she gets up in the morning.

Sadie Grace LeNoble’s Experience

During the podcast, Sadie, at just 13 years old, shared her perspective on her mother’s diagnosis. She expressed the difficulty of watching her once-active mother struggle with the limitations imposed by MS. The emotional toll was evident as she recounted the changes in their daily lives and the adjustments they had to make.

Shared Experiences and Laughter

Despite the challenges, the podcast episode was filled with laughter and shared memories. One particularly amusing story involved their experiences at concerts. Applegate, who uses a wheelchair for mobility, often jokes about Sadie’s eagerness to push her wheelchair, which has led to a few comical mishaps. These moments of levity highlighted the importance of humor in coping with difficult situations.

Applegate’s Struggles with MS

Christina Applegate has been vocal about the struggles she faces daily. From physical pain to emotional stress, she has shared the reality of living with MS with her fans. In a 2023 interview with Vanity Fair, she did not shy away from expressing her frustration, stating that it “fucking sucks.” Her honesty has resonated with many, offering a raw and real look at life with a chronic illness.

Sadie’s Health Challenges

In addition to supporting her mother, Sadie has her own health challenges. She was diagnosed with postural orthostatic tachycardia syndrome (POTS), a condition that causes a rapid increase in heart rate upon standing. Sadie shared her experiences with this condition on the podcast, explaining how it affects her daily life and the steps she takes to manage it.

Understanding Misophonia

Sadie also revealed that she suffers from misophonia, a condition where certain sounds trigger intense emotional responses. Everyday noises like the sound of a vacuum cleaner or classmates chewing can be overwhelming for her. This condition has added another layer of complexity to her life, but she has found ways to cope, such as using noise-canceling headphones and listening to music at low volumes during class.

Coping Mechanisms

To manage her conditions, Sadie has developed various coping mechanisms. Noise-canceling headphones have become an essential tool for dealing with misophonia, while playing music at a low volume helps her stay focused in noisy environments. These strategies have allowed her to maintain a semblance of normalcy despite her challenges.

Mother and Daughter’s Bond

The podcast episode underscored the strong bond between Christina and Sadie. Their relationship has only grown stronger as they navigate their respective health issues. Through mutual understanding and unwavering support, they have found ways to thrive despite the obstacles they face.

Impact of the Podcast

“MeSsy” has become a platform for raising awareness about chronic conditions like MS, POTS, and misophonia. By sharing their personal stories, Christina and Sadie have opened the door to important conversations about health, resilience, and the power of family support. Their candid discussions have resonated with listeners, many of whom have expressed gratitude for the insights and encouragement provided by the podcast.

Public Reception

The response to the podcast episode has been overwhelmingly positive. Listeners appreciate the honesty and vulnerability displayed by Christina and Sadie. The episode has sparked important discussions about living with chronic conditions and the impact these illnesses have on both individuals and their families.

Future Prospects

Looking ahead, Christina Applegate has expressed a desire to continue working, albeit in a different capacity. While she may no longer act in front of the camera, she is open to voiceover work, allowing her to stay connected to her craft. Sadie, meanwhile, remains optimistic about managing her conditions and continues to support her mother every step of the way.


The podcast episode featuring Christina Applegate and her daughter, Sadie Grace LeNoble, was a poignant reminder of the challenges and triumphs that come with living with chronic conditions. Their story is one of resilience, humor, and unbreakable bonds. Through their candid conversations, they have offered hope and support to many, demonstrating that even in the face of adversity, it is possible to find joy and strength.


What is multiple sclerosis? Multiple sclerosis (MS) is a chronic illness that affects the central nervous system, disrupting the flow of information within the brain and between the brain and body. It can cause a wide range of symptoms, including physical, mental, and sometimes psychiatric problems.

What is POTS Syndrome? Postural orthostatic tachycardia syndrome (POTS) is a condition that affects circulation (blood flow). It involves the nervous system and results in symptoms like rapid heart rate, dizziness, and fainting upon standing up.

How does misophonia affect daily life? Misophonia is a condition where specific sounds trigger intense emotional or physiological responses, such as anger or anxiety. Common triggers include chewing, breathing, and tapping noises. It can significantly impact daily activities and interactions.

How can family support individuals with chronic conditions? Family support is crucial for individuals with chronic conditions. This can include emotional support, helping with daily tasks, attending medical appointments, and being understanding and patient with their loved ones’ needs and limitations.

What are some resources for learning about MS, POTS, and misophonia? There are many resources available for learning about these conditions. Websites like the National Multiple Sclerosis Society, Dysautonomia International, and the Misophonia Association provide comprehensive information, support networks, and resources for patients and their families.